Abstract
A WELL-ESTABLISHED fact in clinical dermatology is the frequent occurrence of dermatitis caused by bichromates (hexavalent chromium), while dermatitis caused by trivalent chromium compounds (for example, chromium sulphate) is very rare or non-existent. This seems to be in contradiction with the prevalent opinion that protein-affinity enhances for a given substance its sensitizing capacity. It appeared to me from a large number of experiments with guinea pigs that it is relatively easy to sensitize guinea pigs for chromium with trivalent chromium compounds.
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VAN NEER, F. Sensitization of Guinea Pigs to Chromium Compounds. Nature 198, 1013 (1963). https://doi.org/10.1038/1981013a0
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DOI: https://doi.org/10.1038/1981013a0
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