Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Role of Species Specificity in Failure of Inhibition of Guinea Pig Anaphylactic Sensitization with Cancer Chemotherapy Drugs

Nature volume 197, pages 82–83 (1963)Cite this article

Abstract

THREE years ago Schwarz and Damesheck showed that 6-mercaptopurine could block the formation of antibodies to foreign protein in the rabbit1. This phenomenon has been verified by some, and its existence questioned by others. To understand better the mechanisms involved in the drug-induced antibody blockade, it is necessary to examine those variables which enhance or prevent this blockade of antibody formation. The work reported here gives evidence that the effect of the cancer chemotherapy agents in blocking primary antibody formation depends, at least in part, on the species studied.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Schwarz, R., Eisner, O., and Damesheck, W., J. Clin. Invest., 38, 1394 (1959).

    Article  Google Scholar 

  2. Maguire, H. C., and Maibach, H., J. Allergy, 32, 406 (1961).

    Article  Google Scholar 

  3. Maguire, H. C., Steers, E., and Maibach, H., Federation Meeting (April 1962).

    Google Scholar 

  4. Genghof, D., and Battisto, J., Proc. Soc. Exp. Biol. Med., 107, 93 (1961).

    Article  Google Scholar 

  5. Frisch, A., and Davies, G., J. Immunol., 88, 269 (1962).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Dermatology, Department of Medicine, University of California School of Medicine, San Francisco

    HOWARD I. MAIBACH & HENRY C. MAGUIRE

  2. Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

    HOWARD I. MAIBACH & HENRY C. MAGUIRE

Authors
  1. HOWARD I. MAIBACH
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. HENRY C. MAGUIRE
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

MAIBACH, H., MAGUIRE, H. Role of Species Specificity in Failure of Inhibition of Guinea Pig Anaphylactic Sensitization with Cancer Chemotherapy Drugs. Nature 197, 82–83 (1963). https://doi.org/10.1038/197082a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/197082a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing