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Effect of Potassium Depletion on Lactic Dehydrogenase Activity in the Rat Nephron

Nature volume 196, pages 70–72 (1962)Cite this article

Abstract

IN potassium depletion, the kidney is unable to concentrate the urine properly1,2. Striking morphological changes have been found in the region of the medulla and papilla3,4,5. In addition, marked changes in enzymatic activity, located mainly in the medulla, have been demonstrated by means of histochemical staining methods6. In the work reported here, lactic dehydrogenase activity was measured in various functional units of the kidney of normal and potassium-depleted rats through the use of the quantitative histochemical techniques originated by Lowry7.

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Author notes

  1. SJOERD L. BONTING

    Present address: Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, Bethesda, Maryland

Authors and Affiliations

  1. Departments of Medicine and Biological Chemistry, University of Illinois College of Medicine, and Division of Medicine, Presbyterian-St. Luke's Hospital, Chicago, 12

    ROBERT C. MUEHRCKE & SJOERD L. BONTING

Authors
  1. ROBERT C. MUEHRCKE
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  2. SJOERD L. BONTING
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MUEHRCKE, R., BONTING, S. Effect of Potassium Depletion on Lactic Dehydrogenase Activity in the Rat Nephron. Nature 196, 70–72 (1962). https://doi.org/10.1038/196070b0

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