Abstract
DURING an investigation of the fate of some foreign organic compounds in fish, the metabolism of 3,4-dihydroxyphenylacetic acid (homoprotocatechuic acid) was investigated with the purpose of obtaining some information on methylation reactions in these animals. DeEds et al.1 have noted that this compound is methylated at the 3-hydroxyl group in rats and rabbits. A later report by Scheline et al.2 showed that homoprotocatechuic acid labelled with carbon-14 fed to rabbits at a dose-level of 100 mgm./kgm. resulted in about 85 per cent of the radioactivity being excreted in the urine within 44 hr. While the main excretory product was the original acid, nearly six per cent of the dose was found as 4-hydroxy-3-methoxyphenyl-acetic acid (homovanillic acid).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
DeEds, F., Booth, A. N., and Jones, F. T., J. Biol. Chem., 225, 615 (1957).
Scheline, R. R., Williams, R. T., and Wit, J. G., Nature, 188, 849 (1960).
Wood, J. D., Canad. J. Biochem. Physiol., 36, 1237 (1958).
Axelrod, J., Science, 126, 400 (1957).
Axelrod, J., Physiol. Rev., 39, 751 (1959).
Axelrod, J., and Tomchick, R., J. Biol. Chem., 233, 702 (1958).
Axelrod, J., and Laroche, M. J., Science, 130, 800 (1959).
Udenfriend, S., Creveling, C. R., Ozaki, M., Daly, J. W., and Witkop, B., Arch. Biochem. Biophys., 84, 249 (1959).
Archer, S., Arnold, A., Kullnig, R. K., and Wylie, D. W., Arch. Biochem. Biophys., 87, 153 (1960).
Euler, U. S. v., Acta physiol. Scand., 28, 297 (1953).
Booth, A. N., Masri, M. S., Robbins, D. J., Emerson, O. H., Jones, F. T., and DeEds, F., J. Biol. Chem., 234, 3014 (1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SCHELINE, R. O-Methylation in Fish. Nature 195, 904–905 (1962). https://doi.org/10.1038/195904b0
Issue Date:
DOI: https://doi.org/10.1038/195904b0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
