Abstract
APART from experiments reported in 1954 by Barnes and Duff1, the occurrence of tachyphylaxis to poisons which act by inhibiting cholinesterase has been little publicized, although the phenomenon appears to offer possibilities as a means of investigating cholinergic function. The following is an account of a method which, in a proportion of experiments, was found to lead to a high degree of refractoriness to ‘Sarin’ (isopropyl methyl phosphonofluoridate) in the cat, the conditions being those of tachyphylaxis.
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Barnes, J. M., and Duff, J. I., Brit. J. Pharmacol., 9, 153 (1954).
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DECANDOLE, C. Refractoriness (Tachyphylaxis) to ‘Sarin’. Nature 195, 714 (1962). https://doi.org/10.1038/195714a0
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DOI: https://doi.org/10.1038/195714a0
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