Abstract
THE transfusion of human antihæmophilic globulin concentrate (EHF) routinely prepared in this laboratory by the method of Kekwick and Wolf1 was found to give clinical reactions2 resembling the effects of a plasma kinin3. As EHF contains plasminogen and fibrinogen as well as other clotting factors, and as human plasmin is known to produce a kinin from pseudoglobulins4, the possibility that the reactions were due to a kinin produced as a result of plasminogen activation in EHF was explored.
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MACKAY, M., MAYCOCK, W. & COMBRIDGE, B. Activation of Endogenous Plasma Proteolytic Enzymes with the Consequent Production of Pharmacologically Active Polypeptides. Nature 195, 1206–1207 (1962). https://doi.org/10.1038/1951206a0
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DOI: https://doi.org/10.1038/1951206a0
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