Abstract
SIMPLE derivatives of penicillins, such as esters1 and amides2, have been prepared from the penicillins themselves by conventional methods. The availability of 6-aminopenicillanic acid (6-APA) led me to synthesize from it selected carboxylic derivatives which can be used conveniently to prepare corresponding series of penicillin derivatives by acylation of the appropriate 6-APA intermediate.
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References
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KOE, B. 6-Aminopenicillanamide and Methyl 6-Aminopenicillanate. Nature 195, 1200–1201 (1962). https://doi.org/10.1038/1951200a0
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DOI: https://doi.org/10.1038/1951200a0
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