Abstract
PREVIOUS work has indicated that during graft-versus-host disease in mice, donor elements constitute only a small proportion of the cellular proliferation in the spleen of the hosts1–3. The fate of transplanted homologous cells has been examined experimentally by methods involving discriminant spleen assays of immunologically competent cells1,3, estimation of humoral antibodies following transplantation of spleen cells hyperimmunized against sheep red cells4 and more directly by chromosome analysis of all dividing cells2,5.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Simonsen, M., and Jensen, E., Biological Problems of Grafting, 214 (Blackwell, Oxford, 1959).
Davies, A. J. S., and Doak, S. M. A., Nature, 187, 610 (1960).
Michie, D., Woodruff, M. F. A., and Zeiss, I. M., Immunol., 4, 413 (1961).
Boyse, E. A., Immunol., 2, 170 (1959).
Ford, C. E., Ilbery, P. L. T., and Loutit, J. F., J. Cell. Comp. Physiol., 50, 109 (1957).
Howard, J. G., Michie, D., and Simonsen, M., Brit. J. Exp. Path., 42, 478 (1961).
Gorer, P. A., and Boyse, E. A., Immunol., 2, 182 (1959).
Simonsen, M., Ann. N.Y. Acad. Sci., 87, 382 (1960).
Ford, C. E., Hamerton, J. L., Barnes, D. W. H., and Loutit, J. F., Nature, 177, 452 (1956).
Fox, M., and Zeiss, I. M., Nature, 192, 1213 (1961).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
FOX, M. Cytological Estimation of the Proportion of Proliferating Donor Cells during Graft-versus-Host Disease in F1 Hybrid Mice infected with Parental Spleen Cells. Nature 195, 1024–1025 (1962). https://doi.org/10.1038/1951024a0
Issue Date:
DOI: https://doi.org/10.1038/1951024a0
This article is cited by
-
Successful prevention of homologous disease in mice by means of syngenetic hematopoietic cells
Bulletin of Experimental Biology and Medicine (1972)
-
Interaction of Mouse Spleen Cells in Diffusion Chambers
Nature (1968)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
