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Indirect Action of X-Radiation on Mammalian Cells

Nature volume 195, pages 1012–1013 (1962)Cite this article

Abstract

IONIZING radiations may impair the reproductive capacity of cells either by directly altering specific biochemical sites or indirectly by giving rise to free radicals in water which then react chemically with specific sites. In the frozen state the mobility of free radicals is hindered, and consequently the radio-sensitivity of cells reduced to an extent that depends on the degree to which the indirect mechanism is involved.

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References

  1. Gray, L. H., Rad. Res., 1, 189 (1954).

    Article  CAS  Google Scholar 

  2. Bachofer, C. S., Ehret, C. F., Mayers, S., and Powers, E. L., Proc U.S. Nat. Acad. Sci., 39, 744 (1953).

    Article  ADS  CAS  Google Scholar 

  3. Pollard, E. C., Guild, W. R., Hutchinson, F., and Setlow, R. B., Prog. Biophys., 5, 72 (1950).

    Google Scholar 

  4. Bacq, Z. M., and Alexander, P., Fundamentals of Radiobiology, second ed., 53 (Pergamon Press, Ltd., Oxford, 1961).

    Google Scholar 

  5. Stapleton, G. E., and Edington, C. W., Rad. Res., 5, 39 (1956).

    Article  CAS  Google Scholar 

  6. Rajewsky, B. N., Brit. J. Radiol., 25, 550 (1952).

    Article  CAS  Google Scholar 

  7. Lasnitzki, I., Radiobiol. Symp., Liège, 321 (Butterworth, London, 1954).

  8. Puck, T. T., Prog. Biophys., 10, 238 (1960).

    Google Scholar 

  9. Lovelock, J. E., and Bishop, M. W. H., Nature, 183, 1394 (1959).

    Article  ADS  CAS  Google Scholar 

  10. Ashwood-Smith, M. J., Intern. J. Rad. Biol., 3, 41 (1961).

    CAS  Google Scholar 

  11. Meryman, H. T., Ann. N.Y. Acad. Sci., 85, 503 (1960).

    Article  ADS  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Radiobiological Research Unit, Radiotherapy Department, Institute of Cancer Research, Royal Cancer Hospital, London, S.W.3

    K. B. DAWSON, E. O. FIELD & H. MADOC JONES

Authors
  1. K. B. DAWSON
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  2. E. O. FIELD
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  3. H. MADOC JONES
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DAWSON, K., FIELD, E. & MADOC JONES, H. Indirect Action of X-Radiation on Mammalian Cells. Nature 195, 1012–1013 (1962). https://doi.org/10.1038/1951012b0

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