Abstract
THE excretion of a number of water-soluble azo dyes in rat bile, following intravenous injection, has been previously examined by us1 as a means of estimating the likely extent of uptake and metabolism of these compounds. Among the dyes examined, two phenylazopyrazolones provided highly contrasting results. Tartrazine (1a, R1= COONa, R2 = H) was virtually not excreted at all, whereas lissamine fast yellow 2G (1b, R1 = CH3, R2 = Cl) was excreted quantitatively (Table 1). We have now obtained evidence showing that the carboxyl group of tartrazine is responsible for the difference in excretion.
Similar content being viewed by others
Article PDF
References
Ryan, A. J., and Wright, S. E., J. Pharm. Pharmacol., 13, 1492 (1961).
Fierz-David, H. E., and Blangey, L., Fundamental Processes of Dye Chemistry, 128 (Interscience, New York, 1949).
Williams, R. T., Detoxication Mechanisms, 472 (Chapman and Hall, London, 1959).
Ryan, A. J., and Wright, S. E. (unpublished work).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
RYAN, A., WRIGHT, S. Biliary Excretion of some Azo Dyes related to Tartrazine. Nature 195, 1009 (1962). https://doi.org/10.1038/1951009a0
Issue Date:
DOI: https://doi.org/10.1038/1951009a0
This article is cited by
-
Mutagenic activity in rat urine after feeding with the azo dye tartrazine
Archives of Toxicology (1985)
-
Bacterial Azo Reduction: a Metabolic Reaction in Mammals
Nature (1968)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.