Abstract
FOR the long-term treatment of chronic polyarthritis and collagenosis with hydroxychloroquinsulphate (HS) and hydroxychloroquindiphosphate (HP), accurate adjustment to a definite blood-level would be desirable. Unfortunately, at the present time, there are no specific methods of quantitative determination which can be used by the clinician for both substances. We therefore endeavoured to achieve satisfactory detection of HS and HP by paper chromatography and arrived at the following technique of investigation.
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MÜTING, D. Detection and Metabolism of Hydroxychloroquinsulphate and Hydroxychloroquindiphosphate in Human Beings. Nature 195, 1003–1004 (1962). https://doi.org/10.1038/1951003b0
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DOI: https://doi.org/10.1038/1951003b0
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