Abstract
ALTHOUGH many methods for the assay of thyrotrophic hormone have been described, few have been sensitive enough to detect the amounts of hormone normally circulating in the blood, and all have serious shortcomings from the point of view of statistical validity. The method described by Bottari and Donovan1 involving the measurement of release of iodine-131 from incubated thyroid fragments, while satisfactory from the point of view of sensitivity, suffers from a design which does not lend itself easily to statistical validation. Furthermore, some variation was experienced in the sensitivity of the assay animals, linearity within the stated range of sensitivity was not always obtained, and consequently some erratic results were occasionally encountered.
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References
Bottari, P. M., and Donovan, B. T., J. Physiol., 140, 36 P (1958).
Bliss, C. I., The Statistics of Bioassay (Academic Press, New York, 1952).
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EL KABIR, D. Assay of Thyrotrophic Hormone in Blood. Nature 194, 688–689 (1962). https://doi.org/10.1038/194688a0
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DOI: https://doi.org/10.1038/194688a0
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