Abstract
IT has recently been demonstrated that reparatively growing tissues in skin wounds in the rat produce histamine at a high rate as a result of increased activity of histidine decarboxylase1. Further, the rate of repair, as measured by the tensile strength of the healing wound in situ, can be augmented or retarded, respectively, by artificial increase or inhibition of the histamine-forming capacity of the growing tissues. In these experiments the histamine-forming capacity was increased by injections of the histamine liberator 48/80, which depletes the skin of its histamine content and concomitantly raises the skin level of histidine decarboxylase. Extracellular histamine, derived from injected ‘long-acting histamine’, had no detectable effect on growth in healing. It was concluded that only intracellularly formed ‘nascent’ histamine is active in promoting certain types of growth2.
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SANDBERG, N. Accelerated Collagen Formation and Histamine. Nature 194, 183 (1962). https://doi.org/10.1038/194183a0
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DOI: https://doi.org/10.1038/194183a0
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