Abstract
THE radiosensitivity of hamster cells in vitro was increased by incubation with 5-bromodeoxycytidine prior to X-irradiation. The change in radiosensitivity was determined by a modification of the Puck technique6 in which the survival of clones as a function of X-ray dose was compared with the survival of clones derived from cells incubated for varying periods prior to irradiation in medium containing 5-bromodeoxycytidine. The details of similar experiments in which 5-bromodeoxyuridine and 5-fluorouracil were tested are described elsewhere1,2.
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References
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Puck, T. T., and Marcus, P. I., J. Exp. Med., 103, 653 (1956).
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BAGSHAW, M. Modification of the Radiosensitivity of Hamster Cells in vitro. Nature 193, 389–391 (1962). https://doi.org/10.1038/193389a0
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DOI: https://doi.org/10.1038/193389a0
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