Abstract
THE long-term effect of a single, total-body X-irradiation on the size of the kidneys in the intact mouse has been studied by Kohn, Kallman, Bordjis and De Ome1, Esnouf, Ord and Stocken2 and by Franklin3. All were agreed that the kidneys of irradiated male animals were smaller than those of the unexposed controls whereas those of the irradiated females were not appreciably different from the control values. The growth of the kidney in the adult rodent is normally slow, and it seemed of interest to determine whether a sub-lethal total-body X-irradiation had any long-term effect on the rapid renal growth induced by a unilateral nephrectomy. In the present experiment white rats of the Wistar strain were used because of their greater convenience.
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References
Kohn, H. I., Kallman, R. F., Bordjis, C. C., and De Ome, K. B., Rad. Res., 7, 407 (1957).
Esnouf, M. P., Ord, M. G., and Stocken, L. A., Intern. J. Rad. Biol., 5, 459 (1961).
Franklin, T. J., Intern. J. Rad. Biol., 5, 467 (1961).
Kennedy, G. C., Colloquia on Ageing, 250, Ciba Foundation (J. and A. Churchill, Ltd., London, 1958).
Cameron, G. R., Pathology of the Cell, 422 (Oliver and Boyd, London, 1952).
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FRANKLIN, T. Long-Term Effect of Total-Body X-irradiation on the Compensatory Hypertrophy of the Rat Kidney. Nature 193, 289–290 (1962). https://doi.org/10.1038/193289a0
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DOI: https://doi.org/10.1038/193289a0
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