Abstract
VARIATIONS in the mean content of deoxyribo-nucleic acid (DNA) in the nuclei correlated with cell-activity has been observed in several organs1: thyroid gland2, interstitial cells of the testis3, medulla4 and cortex5 of the adrenal gland. Stimulation of cell activity appeared to be accompanied by an increase, an inhibition of cell activity by a decrease, of the nuclear DNA. These results were obtained by comparing control animals with test animals, which had previously been subjected to 14 days of experimental conditions. Also for a shorter period, considerable changes of the DNA content can occur, such as has been demonstrated, in relation to the sex cycle (5 days) of the female rat, in vaginal epithelium6, granulosa cells in the ovary7, and adrenal cortex8.
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VERWOERD-VERHOEF, H., VERWOERD, C. Start and Progress of Increase of Nuclear Deoxyribonucleic Acid Content after Stimulation of Cell Activity. Nature 193, 1208 (1962). https://doi.org/10.1038/1931208a0
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DOI: https://doi.org/10.1038/1931208a0
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