Abstract
TO examine the exact mechanism of reproduction of the tick-borne encephalitis virus in susceptible host cells in vitro, the intracellular proliferation and release of the virus into the medium have been compared with the sequence of morphological changes studied by different methods. HeLa cell monolayer cultures were used, infected with a large or a small dose of a selected variant of the Czechoslovak strain Hypr of tick-borne encephalitis virus1, which is cytopathic for HeLa cells.
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References
Libíková, H., and Vilček, J., Acta virologica, 4, 165 (1960).
Riggs, J. L., Seiwald, R. J., Bruckhalter, J., Downs, C. M., and Metcalf, T. G., Amer. J. Path., 34, 1081 (1958).
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LIBÍKOVÁ, H., ALBRECHT, P. Reproduction of Tick-borne Encephalitis Virus in HeLa Cells. Nature 192, 779–780 (1961). https://doi.org/10.1038/192779a0
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DOI: https://doi.org/10.1038/192779a0
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