Abstract
THE group-specific components of sera consist of electrophoretically variable α2-globulins demonstrable by means of an immuno-electrophoretic technique1. This system allows a division of human sera into three qualitatively different patterns characterized by the presence of a fast-moving group-specific component (Gc 1–1), a slow-moving component (Gc 2–2), which in immuno-electrophoresis both give normally arc-shaped precipitates, or the simultaneous presence of both fast- and slow-moving components (Gc 2–1), which in immuno-electrophoresis give an extended two-peaked precipitate due to a reaction of immunological identity between these electrophoretically different although immunologically identical fast-and slow-moving components1. Investigations on sera from 42 families with 137 children and more than 600 mother–child combinations have shown that these serum patterns are genetically determined by two autosomal alleles (Gc1 and Gc2) without dominance where the serum types Gc 1–1 and Gc 2–2 are the homozygotes and Gc 2–1 the heterozygote. Up to now, no exceptions to this genetical theory or unresolved typing difficulties has been found in the material investigated2,3.
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Hirschfeld, J., Acta Path. Microbiol. Scand., 47, 160 (1959); Science Tools, 7, 18 (1960).
Hirschfeld, J., Jonsson, B., and Rasmuson, M., Nature, 185, 931 (1960).
Hirschfeld, J., Progress in Allergy (in the press).
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HIRSCHFELD, J., SONNET, J. Distribution of Group-specific Components (Gc) in the Sera of Native Africans. Nature 192, 766 (1961). https://doi.org/10.1038/192766a0
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DOI: https://doi.org/10.1038/192766a0
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