Abstract
A NUMBER of methods for the radioiodination of proteins and amino-acids have been described1,2. Some have relied on transfer of elemental iodine from an oxidizing medium by extraction with an organic solvent; in others oxidation of iodide to iodine has been effected in the presence of the material to be iodinated with the associated risk of damage to the latter by the oxidizing reagent in the mixture.
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References
McFarlane, A. S., Biochem. J., 62, 135 (1956).
Yalow, R. S., and Berson, S. A., J. Clin. Invest, 39, 1157 (1960).
Conway, E. J., Microdiffusion Analysis and Volumetric Error (Crosby, Lockwood, London, 1947).
Fenton, E. L., Biochem. J., 71, 507 (1959).
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BANERJEE, R., EKINS, R. A Simple Microdiffusion Technique for the Radioiodination of Proteins. Nature 192, 746–747 (1961). https://doi.org/10.1038/192746a0
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DOI: https://doi.org/10.1038/192746a0
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