Abstract
PRIMARY tumours induced by polycyclic hydrocarbons have been examined by several investigators to evaluate the importance of karyotype modification in carcinogenesis1–3. A significant number of such tumours has been characterized by cells with aneuploid chromosome numbers. In a study of 14 fibrosarcomas induced by methylcholanthrene in a variety of F1 hybrids of inbred mouse strains, Hellström2 reported that only 4 tumours contained predominantly diploid cells. The cells comprising the remaining ten tumours were either hyperdiploid, triploid, or hypertetraploid. Marked variability in chromosomal pattern was observed from one tumour to another as well as within any one tumour.
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References
Bayreuther, K., Nature, 186, 6 (1960).
Hellström, K. E., J. Nat. Cancer Inst., 23, 1019 (1959).
Stich, H. F., J. Nat. Cancer Inst., 25, 649 (1960).
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BIEDLER, J., OLD, L. & CLARKE, D. Chromosomal Lesion associated with Carcinogen-induced Tumours in Mice. Nature 192, 286–288 (1961). https://doi.org/10.1038/192286a0
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DOI: https://doi.org/10.1038/192286a0
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