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Failure of the Purified Growth Hormone to restore the Size of the Kidneys in Hypophysectomized Rats

Abstract

IN previous work the effect of hypophysectomy on the size of the remaining kidney after unilateral nephrectomy was investigated in dogs and rats1. After hypophysectomy rats, unlike dogs, lose weight or fail to grow normally. It is, therefore, difficult to assess whether the failure of the remaining kidney to hypertrophy is a non-specific effect or the result of a deficiency of (a) particular hormone(s). Bearing this in mind, it seemed necessary to study the effect of growth hormone.

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References

  1. Astarabadi, T., and Essex, H. E., Amer. J. Phys., 173, 326 (1953).

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  3. De Rodo, R. C., et al., Fed. Proc., 10, 33 (1951).

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  4. Earl, D. P., et al., Amer. J. Phys., 173, 188 (1953).

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ASTARABADI, T. Failure of the Purified Growth Hormone to restore the Size of the Kidneys in Hypophysectomized Rats. Nature 192, 270–271 (1961). https://doi.org/10.1038/192270a0

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  • DOI: https://doi.org/10.1038/192270a0

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