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Effect of Calf Thymus Histone on Rats bearing Transplantable Acute Myeloid Leukæmia

Abstract

THE bactericidal activity and the cytotoxic effect of basic proteins, protamines and histones have been investigated by different workers. However, the cytostatic effect of histones on tumour cells in vitro1–3 and in vivo4 deserves more attention. Do histones possess a specific growth regulatory activity as was suggested by Zbarskii4, are they gene inhibitors as Stedman has outlined in his theory5, or is the inhibitory action of histones on tumours due only to their high toxicity in the experimented animals ?

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HNILICA, L., HOLOUBEK, V. Effect of Calf Thymus Histone on Rats bearing Transplantable Acute Myeloid Leukæmia. Nature 191, 922–923 (1961). https://doi.org/10.1038/191922b0

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