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Kinetics of the Enzymic Degradation of Deoxyribonucleic Acid into Sub-units

Nature volume 191, pages 809–810 (1961)Cite this article

Abstract

RECENT reports from this laboratory1,2 described the enzymic degradation of deoxyribonucleic acid (DNA) into rod-like sub-units having a molecular weight of 5–6 × 105 and a Watson and Crick3 double helical structure. No production of dialysable nucleotides and no increase of the ultra-violet absorption coefficient at 260 mµ were detectable during the digestion. It is the purpose of this communication to report further information obtained by using a purified enzyme preparation.

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References

  1. Bernardi, G., Champagne, M., and Sadron, C., Nature, 188, 228 (1960).

    Article  ADS  CAS  Google Scholar 

  2. Bernardi, G., Champagne, M., and Sadron, C., Biochim. Biophys. Acta, 49, 1 (1961).

    Article  CAS  Google Scholar 

  3. Watson, J. D., and Crick, F. H. C., Nature, 171, 737 (1953).

    Article  ADS  CAS  Google Scholar 

  4. Bernardi, G. (manuscript in preparation).

  5. Sadron, C., The Nucleic Acids, 3, 1, edit. by Chargaff, E., and Davidson, J. N. (Academic Press, New York, 1960).

    Book  Google Scholar 

  6. Bernardi, G., Biochim. Biophys Acta (in the press).

  7. Oth, A., Frédéricq, E., and Hacha, R., Biochim. Biophys. Acta, 29, 287 (1958).

    Article  CAS  Google Scholar 

  8. Schumaker, V. N., Richards, E. G., and Schachman, H. K., J. Amer. Chem. Soc., 78, 4230 (1956).

    Article  CAS  Google Scholar 

  9. Thomas, C. A., J. Amer. Chem. Soc., 78, 1861 (1956).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Centre de Recherches sur les Macromolécules, Strasbourg

    GIORGIO BERNARDI & CHARLES SADRON

Authors
  1. GIORGIO BERNARDI
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  2. CHARLES SADRON
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BERNARDI, G., SADRON, C. Kinetics of the Enzymic Degradation of Deoxyribonucleic Acid into Sub-units. Nature 191, 809–810 (1961). https://doi.org/10.1038/191809a0

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