Abstract
THE hydroxylation of aromatic compounds in vivo is well known1, and polycyclic aromatic hydrocarbons2 and aromatic amino-acids and related compounds3 have been found to be hydroxylated by suitably fortified suspensions of rodent liver microsomes. Aromatic amino-acids and related compounds are also hydroxylated non-enzymically in phosphate buffer solutions containing iron and ascorbic acid in the presence of oxygen4,5, or in hydrogen peroxide solutions containing Fe++ (ref. 6). In the case of polycyclic aromatic hydrocarbons slow conversion to quinones, by ascorbic acid7, and more rapid oxidation by hydrogen peroxide8, have been reported.
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DEWHURST, F., CALCUTT, G. Non-Enzymic Hydroxylation of Polycyclic Aromatic Hydrocarbons. Nature 191, 808–809 (1961). https://doi.org/10.1038/191808a0
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DOI: https://doi.org/10.1038/191808a0
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