Abstract
PHASE-CONTRAST observation and electron microscopy indicate that the nucleolus is structurally heterogeneous consisting of a ground material in which is embedded a more compactly aggregated material generally described as filamentous (Estable and Sotelo1 proposed for them the names of ‘pars amorpha’ and ‘nucleolonema’). Nucleoli of plant and animal cells are seen at mitosis and meiosis associated with a particular chromosome or chromosomes—the so-called ‘nucleolar organizer’ chromosomes—at the site of a heterochromatic region. If a chromosomal deletion includes such a region or if a mutation occurs2, nucleolar material is then produced at other ‘loci’ (the latent organizers).
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References
Estable, C., and Sotelo, J. R., Inst. Invest. Ciencias Biol., 1, 105 (1951).
Fischberg, M., and Wallace, H., The Cell Nucleus, edit. by Holmes, B., 30 (1960).
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Lettre, R., Symp. Fine Structure of Cells, 141 (Noordhoff, Groningen, 1956).
Lettre, R., Tenth Congr. Cell. Biol., 1960 (in the press).
Estable, C., and Sotelo, J. R., Symp. Fine Structure of Cells, 170 (Noordhoff, Groningen, 1956).
Godward, M. B. E., Ann. Bot., 14, 39 (1950).
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O'DONNELL, E. Deoxyribonucleic Acid Structures in the Nucleolus. Nature 191, 1325–1326 (1961). https://doi.org/10.1038/1911325a0
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DOI: https://doi.org/10.1038/1911325a0
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