Abstract
PHYSICOCHEMICAL work shows that ionizing radiations cause fragmentation and aggregation of protein molecules1–3. When protein molecules are degraded there is a variety of products and also many amino-acids are degraded. However, the mechanisms by which these changes occur are still obscure. In our experiments, we define the radiation damage to cyto-chrome c, hæmoglobin, catalase, and egg albumin in terms of radiation-lability of amino-acids and loss of biological properties of the three hæmoproteins. The amino-acid pattern of scission products and insoluble protein aggregates was also determined.
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KUMTA, U., TAPPEL, A. Radiation Damage to Proteins. Nature 191, 1304–1305 (1961). https://doi.org/10.1038/1911304a0
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DOI: https://doi.org/10.1038/1911304a0
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