Abstract
THE procedures for the estimation of enzymes of the urea cycle reported by Brown and Cohen1 have made it possible to study quantitatively the effect of hormones on the individual reactions of the urea cycle. These authors have recently shown that, in rat liver, the condensing enzyme of the arginine synthetase system is rate-limiting and will thus be a pacemaker for the whole system2. It is at such rate-limiting reactions that metabolic control might be exerted, and it therefore seemed of particular interest to measure the activity of this enzyme under conditions where there is a marked change in nitrogen metabolism and the production of urea.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Brown, jun., G. W., and Cohen, P. P., J. Biol. Chem., 234, 1769 (1959).
Brown, jun., G. W., and Cohen, P. P., Biochem. J., 75, 82 (1960).
Long, C. N. H., Katzin, B., and Fry, E. G., Endocrinol., 26, 309 (1940).
Young, F. G., Ann. Rep. Chem. Soc., 42, 214 (1945).
Fraenkel-Conrat, H., Simpson, M. E., and Evans, H. M., J. Biol. Chem., 147, 99 (1943).
Folley, S. J., and Greenbaum, A. L., Biochem. J., 43, 581 (1948).
Folley, S. J., and Greenbaum, A. L., Biochem. J., 43, 537 (1948).
Nazario, M., and Cohen, P. P., Proc. Soc. Exp. Biol. Med., 106, 492 (1961).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
McLEAN, P. Effect of Adrenalectomy on the Activity of Enyzmes of the Urea Cycle in Rat Liver. Nature 191, 1302–1303 (1961). https://doi.org/10.1038/1911302b0
Issue Date:
DOI: https://doi.org/10.1038/1911302b0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
