Abstract
PYRIMIDINE analogues may interfere with nucleic acid metabolism by inhibition of the conversion of the free pyrimidine bases to the corresponding nucleotides or by production of abnormal nucleic acids containing substituted pyrimidines. Recently it has been found that an analogue may also function by negative feed-back control and thus inhibit the formation of the normal metabolite1,2.
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ZAMIR, A., BEN-ISHAI, R. A Requirement for 2-Thiouracil of 2-Thiouracil-grown Escherichia coli under Conditions of Ornithine Transcarbamylase Repression. Nature 189, 922–923 (1961). https://doi.org/10.1038/189922a0
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DOI: https://doi.org/10.1038/189922a0
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