Abstract
IN 1953, the isolation of a new virus termed hepatoencephalomyelitis virus was described1. This was recovered from the fæces of an aboriginal child suffering from a respiratory infection and who later developed alopecia areata. Further work2 on this virus revealed the following properties: (1) Production of clinically recognizable disease only in suckling mice (commonly observed signs: oily hair, jaundice, peritoneal exudate, ataxia; a ‘neurotropic’ variant killed infant mice rapidly without these clinical signs). (2) Typical lesions in suckling mice were observed in the brain, cord, liver and heart. (3) Membranes of 110 mµ average pore diameter withheld virus; those of 130 mµ average pore diameter did not. (4) Resistance to ether. (5) Growth in tissue culture and chick embryos. (6) Infection in mice associated with the increased production of fæcal material of exceptionally high fat content. (7) The infection could be transmitted orally to suckling mice.
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Stanley, N. F., Dorman, D. C., and Ponsford, J., Austral. J. Exp. Biol. and Med. Sci., 31, 147 (1953).
Stanley, N. F., Dorman, D. C., and Ponsford, J., Austral. J. Exp. Biol. and Med. Sci., 32, 543 (1954).
van Tongeren, H. A. E., Arch. Ges. Virusforsch., 7, 429 (1957).
Sabin, A. B., Science, 130, 1387 (1959).
Rosen, L., Amer. J. Hyg., 71, 242 (1960).
Rosen, L., and Abinanti, F. R., Amer. J. Hyg., 71, 250 (1960). Rosen, L., Hovis, J. F., Mastrota, F. M., Bell, J. A., and Huebner, R. J., Amer. J. Hyg., 71, 258 and 266 (1960).
Ramos-Alvarez, M., Ann. N.Y. Acad. Sci., 67, 326 (1957). Hull, R. N., Minner, J. R., and Smith, J. W., Amer. J. Hyg., 63, 204 (1956). Hull, R. N., Minner, J. R., and Mascoli, C. C., ibid., 68, 31 (1958).
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STANLEY, N. Relationship of Hepatoencephalomyelitis Virus and Reoviruses. Nature 189, 687 (1961). https://doi.org/10.1038/189687a0
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DOI: https://doi.org/10.1038/189687a0
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