Abstract
ENDOCRINE organs are able to maintain high concentration gradients between their secretory cells and the extracellular fluid. The mechanisms for maintaining this gradient are not clear, although restraining the hormones within a semipermeable membranous structure could sub-serve this function. Herlant1 and Brown and Hess2 have shown that many hormones of the anterior pituitary are stored in a particulate form. In addition, the work of Hillarp et al. 3 and Blaschko and Welch4 indicates that adrenaline and noradrenaline are stored in granules within the adrenomedullary cells.
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References
Herlant, M., Ann. d'Endocrin., 13, 611 (1952).
Brown, J. H. V., and Hess, M., Amer. J. Physiol., 188, 25 (1957).
Hillarp, N. A., Lagerstedt, S., and Nilsson, B., Acta Physiol. Scand., 29, 251 (1953).
Blaschko, H., and Welch, A. D., Arch. Exp. Path. u. Pharmakol., 219, 17 (1953).
Rosenfield, M., Bull. J. Hopkins Hosp., 66, 398 (1940).
Andersson, B., and Persson, N., Acta Physiol. Scand., 42, 257 (1958).
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SCHAPIRO, S., STJARNE, L. Evidence for the Granular Localization of Posterior Pituitary Hormones. Nature 189, 669 (1961). https://doi.org/10.1038/189669a0
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DOI: https://doi.org/10.1038/189669a0
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