Abstract
PREVIOUS investigations by Trout1 and by us2 indicate clearly that the deposition of mineral in the aortæ of calciferol-intoxicated rats continued long after cessation of administration of this compound and after the blood calcium-level had returned to normal. It appears that, once initiated, this process follows an irreversible course, at least in the aorta, since even 160 days after the initial insult there was no evidence of a reduction in the mineral content of the aorta. Attempts to inhibit calciferol-induced calcification of the aorta by the simultaneous administration of papain (which reduces the mucopolysaccharide content of the aorta) were unsuccessful3.
Similar content being viewed by others
Article PDF
References
Trout, G. E., S. Afr. J. Med. Sci., 22, 157 (1958).
Gillman, T., Grant, R. A., and Hathorn, M., Brit. J. Exp. Path., 41, 1 (1960).
Grant, R. A., Hathorn, M., and Gillman, T., Biochem. J., 76, 412 (1960).
Whitehead, R. G., and Weidman, S. M., Biochem. J., 72, 667 (1958).
Gutman, A. B., and Yii, T. F., Trans. First Macey Conf. Metabolic Interrelations, 1, 11 (1949).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GRANT, R., HATHORN, M. & GILLMAN, T. Inhibiting Effect of 2 : 4-Dinitrophenol on Calciferol-induced Metastatic Calcification in the Rat. Nature 189, 317 (1961). https://doi.org/10.1038/189317a0
Issue Date:
DOI: https://doi.org/10.1038/189317a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.