Abstract
GROWTH hormone administered to normal, diabetic or hypophysectomized dogs produces severe toxic reactions which may terminate fatally1. Human anterior pituitary preparations may also precipitate severe toxic reactions in spontaneous human diabetes and mild reactions even in non-diabetics2,3. Similarly, saline suspensions of acetone-dried, human anterior pituitary lead to fatal reactions in insulin-deprived, depancreatized baboons4. Cortisone prevents the adverse reactions of growth hormone in hypophysectomized dogs5, but not in diabetic baboons4.
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Campbell, J., Munroe, J. S., Hausler, H. R., and Davidson, I. W. F., Endocrinol., 53, 549 (1953).
Ikkos, D., Luft, R., and Gemzell, C. A., The Lancet, No. 7023, 720 (1958).
Luft, R., Ikkos, D., Gemzell, C. A., and Olivecrona, H., The Lancet, No.7023, 721 (1958).
Gillman, J., Gilbert, C., Epstein, E., and Allan, J. C., Brit. Med. J., ii, 1260 (1958).
de Bodo, R. C., Sinkoif, M. W., Kiang, S. P., and Den, H., Proc. Soc. Exp. Biol. Med., 81, 425 (1952).
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GILLMAN, J., GILBERT, C. & EPSTEIN, E. Importance of Insulin and of the Adrenal Cortex in determining the Toxicity in Baboons (Papio ursinus) of Human Anterior Pituitary. Nature 188, 861–862 (1960). https://doi.org/10.1038/188861a0
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DOI: https://doi.org/10.1038/188861a0
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