Abstract
WORKERS studying the phagocytic activity of tumour cells seem to prefer in vitro systems1,2. Little work appears to have been done on the ability of tumour cells to take up colloidal or particulate substances in vivo. Because of the possible practical importance of the subject, it was decided to study the reticulo-endothelial activity of mouse tumours. Acetone-killed, radioiodinated Brucella abortus (131IBr) were chosen as the test particle, since previous work3 had shown that these bacteria are a very sensitive indicator of phagocytic activity.
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References
Gropp, A., and Hupe, Kl., Z. Krebsforschung, 61, 263 (1956).
Shepard, C. C., Fed. Proc., 17, 534 (1958).
Sulitzeanu, D., Bdolach, A., and Sperling, O., J. Immunol., 84, 551 (1960).
Sulitzeanu, D., J. Immunol., 82, 304 (1959).
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SULITZEANU, D. Localization of Radioactivity in Tumours of Mice injected intravenously with Killed, Radioiodinated Brucella abortus . Nature 188, 757–758 (1960). https://doi.org/10.1038/188757a0
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DOI: https://doi.org/10.1038/188757a0
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