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An Indicator Plaque-forming System for Demonstration of Interference by Noncytocidal Strains of Rabies Virus

Nature volume 186, pages 821–822 (1960)Cite this article

Abstract

FIXED strains of rabies virus are known to multiply in chick embryo tissues1,2. So far, however, a cytocidal effect of the virus on monolayers of primary chick embryo cell cultures has not been observed. Since chick embryo-adapted strains of rabies virus interfere with infection by homologous virus in animal cells3, the present investigations were undertaken to demonstrate interference of rabies virus with a superimposed infection of western equine encephalitis virus, which is known to produce cytopathic changes in these cultures.

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Author notes

  1. MARTIN M. KAPLAN: On leave of absence from the World Health Organization, Geneva.

  2. ZLATKO FORSEK: On leave of absence from the Veterinary School, University of Sarajevo.

Authors and Affiliations

  1. Wistar Institute, Philadelphia

    MARTIN M. KAPLAN, EBERHARD WECKER, ZLATKO FORSEK & HILARY KOPROWSKI

Authors
  1. MARTIN M. KAPLAN
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  2. EBERHARD WECKER
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  3. ZLATKO FORSEK
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  4. HILARY KOPROWSKI
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KAPLAN, M., WECKER, E., FORSEK, Z. et al. An Indicator Plaque-forming System for Demonstration of Interference by Noncytocidal Strains of Rabies Virus. Nature 186, 821–822 (1960). https://doi.org/10.1038/186821a0

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