Acetylation of 4-Quinazolone

Abstract

THE sodium salt of 4-quinazolone¹ is known to give 3-substituted derivatives on alkylation¹. In the hope of preparing 3-acetyl-4-quinazolone, the sodium salt of 4-quinazolone was subjected to acetylation. When carefully dried sodium salt of 4-quinazolone was made to react with acetyl chloride in dry dioxane, a colourless crystalline compound C₁₀H₈O₂N₂, was isolated. The same derivative was obtained by refluxing 4-quinazolone with large excess of acetic anhydride. Extreme care was necessary in excluding water during the preparation and purification of this compound.