Abstract
THE growing recognition that the immunological responses initiated by certain micro-organisms are not necessarily limited in their scope, but may be manifested towards taxonomically and antigenically heterologous organisms1, raises the question of whether many states of specifically acquired immunity rest entirely on specific mechanisms. The increased resistance which accrues to survivors of a first infection, or which follows a specific immunization procedure, may not always be based on specific immunological reactions, that is, those involving antibody or tissue hypersensitivity, but may result from the same non-specific effects which underlie the development of heterologously orientated changes in immunity.
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References
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It has been reported previously that tuberculous and leprous diseases confer resistance on man and on laboratory animals against plague infection ( Girard, G., and Grumbach, F., C.R. Soc. Biol., Paris, 152, 280 (1958); Rep. Internat. Plague Conf., Mukden, 1911).
The EV 76 strain of P. pestus is relatively a virulent ( Walker, D. L., et al., J. Immunol., 70, 245 (1953)), but kills mice when given in large numbers.
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WEISS, D. Enhanced Resistance of Mice to Infection with Pasteurella pestis following Vaccination with Fractions of Phenolkilled Tubercle Bacilli. Nature 186, 1060–1061 (1960). https://doi.org/10.1038/1861060a0
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DOI: https://doi.org/10.1038/1861060a0
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