Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Incorporation of α,ω-Dicarboxylic Acids as Side-chains into the Penicillin Molecule

Nature volume 185, pages 97–99 (1960)Cite this article

Abstract

WHILE a considerable number of biosynthetic penicillins have been obtained by adding different side-chain precursors to the culture medium, the incorporation of aliphatic dicarboxylic acids into the penicillin molecule does not as yet seem to have been reported.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Backus, M. P., and Stauffer, J. F., Mycologia, 47, 429 (1955).

    Article  Google Scholar 

  2. Jarvis, F. G., and Johnson, M. J., J. Amer. Chem. Soc., 69, 3010 (1947).

    Article  CAS  Google Scholar 

  3. Paladino, S., Ugolini, F., and Chain, E. B., Rend. Ist. Sup. Sanità (English edition), 17, 87 (1954).

    Google Scholar 

  4. Whiffen, A. J., and Savage, G. M., J. Bact., 53, 231 (1947).

    CAS  PubMed  Google Scholar 

  5. Abraham, E. P., Newton, G. G. F., and Hale, C. W., Biochem. J., 58, 94 (1954).

    Article  CAS  Google Scholar 

  6. Ford, J. H., Indust. Eng. Chem., Anal. Edit., 19, 1004 (1947).

    CAS  Google Scholar 

  7. Van Heyningen, W. E., Brit. J. Exp. Path., 30, 302 (1949).

    CAS  PubMed  Google Scholar 

  8. Heatley, N. G., and Florey, H. W., Brit. J. Pharmacol., 8, 252 (1953).

    CAS  Google Scholar 

  9. Paladino, S., Rend. Ist. Sup. Sanità (English edition), 17, 145 (1954).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. International Centre for Chemical Microbiology, Istituto Superiore di Sanità, Rome

    A. BALLIO, E. B. CHAIN, F. DENTICE DI ACCADIA, MARIA FRANCESCA MASTROPIETRO-CANCELLIERI, G. MORPURGO, G. SERLUPI-CRESCENZI & G. SERMONTI

Authors
  1. A. BALLIO
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. B. CHAIN
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. DENTICE DI ACCADIA
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. MARIA FRANCESCA MASTROPIETRO-CANCELLIERI
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. MORPURGO
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. G. SERLUPI-CRESCENZI
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. G. SERMONTI
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

BALLIO, A., CHAIN, E., DI ACCADIA, F. et al. Incorporation of α,ω-Dicarboxylic Acids as Side-chains into the Penicillin Molecule. Nature 185, 97–99 (1960). https://doi.org/10.1038/185097a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/185097a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing