Abstract
FROM a number of recent papers it appears that the mobilization and transport of fat from fat depots to sites of its further utilization take place mostly in the form of non-esterified fatty acids1. Evidence that this is so is provided by Dole2 and Gordon3 who observed during states with an inadequate utilization of carbohydrates an elevated blood level of non-esterified fatty acid. When the utilization of carbohydrates was increased (after ingestion of glucose or after administration of insulin) the blood level of non-esterified fatty acids decreased. Experiments with adipose tissue in vitro also confirmed that under certain conditions non-esterified fatty acids can be released. The amount released depends on whether at the moment the animal was killed the energy requirements were satisfied from reserves. Gordon and Cherkes4 have demonstrated an increased release of non-esterified fatty acids from incubated epididymal fat of fasting rats, while during satiety the release was insignificant. It was also revealed that the release of non-esterified fatty acids from incubated adipose tissue of normal animals is increased by various hormones added in vitro: adrenalin4, noradrenalin, corti-cotropin5,6, while its release is arrested after the addition of insulin4. Thus, it can be assumed that the adipose tissue of diabetic animals, which must mobilize fat reserves, will also, in vitro, release more non-esterified fatty acids than the tissue of healthy animals. Our experiments confirm this assumption.
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References
Fredrickson, D. S., and Gordon, R. S., Jun., Physiol. Rev., 38, 585 (1958).
Dole, V. P., J. Clin. Invest., 35, 150 (1956).
Gordon, R. S., Jun., and Cherkes, A., J. Clin. Invest., 35, 206 (1956).
Gordon, R. S., jun., Cherkes, A., idem., Proc. Soc. Exp. Biol. Med., 97, 150 (1958).
White, J. E., and Engel, F. L., J. Clin. Invest., 37, 942 (1958).
Idem., ibid., 37, 1556 (1958).
Wenke, M., Wenkeová, J., Skrobal, D., Mühlbachová, E., and Zita, C., Acta Univ. Carolinae-Medica, 1–3, 462 (1958).
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WENKEOVÁ, J., PÁV, J. Release of Non-Esterified Fatty Acids from Adipose Tissue in Normal and Diabetic Rats. Nature 184, 1147 (1959). https://doi.org/10.1038/1841147a0
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DOI: https://doi.org/10.1038/1841147a0
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