Abstract
DURING the course of toxicity studies in male rats (WR), isologous bone marrow from female animals was transplanted to counteract depressing action on the bone marrow of the compound under evaluation. A search was made for a biological marker characteristic of the donor identifiable in the host and the presence of a structural difference between nuclei of male and female neutrophilic leucocytes as described for humans1, rabbits2, and dogs3 was confirmed also for rats.
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References
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MEIER, H. A Sex Difference in White Blood Cells of Rats (WR Strain). Nature 184, 1082–1083 (1959). https://doi.org/10.1038/1841082b0
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DOI: https://doi.org/10.1038/1841082b0
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