Abstract
γ-BUTYROBETAINE is a substance which has been known for many years to be present in the tissues of some cold-blooded animals, for example, snakes (Python)1 and freshwater eels2. It appears, however, not to be present normally in mammalian tissues, but it has been located in muscle extract3 and decaying horse flesh4, and may appear in the urine in phosphorous poisoning5 or in pernicious anæmia6. Linneweh7 has shown that γ-butyrobetaine injected into dogs is largely excreted unchanged, although a small proportion is oxidized to carnitine.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Keil, W., Linneweh, W., and Poller, K., Z. Biol., 86, 187 (1927).
Hoppe-Seyler, F. A., and Schmidt, W., Z. Biol., 87, 69 (1927).
Gulewitsch, W., and Krimberg, R., Z. physiol. Chem., 45, 326 (1905).
Brieger, L., Uber Ptomaine, 3, 30 (1886).
Takeda, K., Pflügers Arch. ges. Physiol., 133, 365 (1910).
Reinwein, H., and Thielman, F., Arch. exp. path. Pharmakol., 103, 115 (1924).
Linneweh, W., Z. physiol. Chem., 181, 42 (1929).
Hosein, E. A., Canad. J. Biochem. Physiol. (in the press).
Brown, G. L., J. Physiol., 89, 220 (1937).
Florey, E., and McLennan, H., J. Physiol. (in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HOSEIN, E., MCLENNAN, H. Pharmacological Actions of γ-Butyrobetaine. Nature 183, 328–329 (1959). https://doi.org/10.1038/183328a0
Issue Date:
DOI: https://doi.org/10.1038/183328a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.