Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

A Paper Chromatography Method for the Determination of Suitable pH Values for the Extraction of Antibiotics

Nature volume 182, pages 796–797 (1958)Cite this article

Abstract

EXTRACTION methods are usually used for the isolation and purification of antibiotics soluble in organic solvents which are immiscible with water. This method can be applied if the partition coefficient of the antibiotic between the solvent and water is sufficiently large. The partition coefficient often depends on the pH. value, particularly for acidic or basic compounds.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Ševčík, V., Podojil, M., and Vrtišková, A., Csl. Mikrobiol., 2, 175 (1957).

    Google Scholar 

  2. Betina, V., and Pilátová, L., Csl. Mikrobiol., 3, 202 (1958).

    Google Scholar 

  3. Block, J. R., Durrum, E. L., and Zweig, G., “A Manual of Paper Chromatography and Paper Electrophoresis” (New York, 1955).

    Google Scholar 

  4. Betina, V., Chemické zvesti (in the press).

  5. Underkofler, L. A., and Hickey, R. J., “Industrial Fermentations,”, 2 (New York, 1954).

  6. Herold, M., Vondráček, M., Nečásek, J., and Doskočil, J., “Antibiotika” (Prague, 1957).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Technical Microbiology and Biochemistry, Slovak Polytechnical University, Bratislava

    VLADIMÍR BETINA

Authors
  1. VLADIMÍR BETINA
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

BETINA, V. A Paper Chromatography Method for the Determination of Suitable pH Values for the Extraction of Antibiotics. Nature 182, 796–797 (1958). https://doi.org/10.1038/182796a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/182796a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing