Abstract
IT was initially observed by Nicol1 that, following the administration of œstrogenic hormones, there was stimulation of the activity of phagocytic cells in the endometrium. This work was extended later to include both natural and synthetic œstrogens2–4, and these findings indicated that in both male and female animals œstrogens possess a strong stimulating influence on the reticulo-endothelial system, which results in the appearance of large numbers of macrophages in the spleen, liver and lymph nodes, and the mobilization of these macrophages into the circulation. In the above researches, the try pan blue method was used to assess the activity of the reticulo-endothelial phagocytes. These results have since been confirmed by the carbon method, and it has been found that the strongest stimulants of the reticulo-endothelial system possess high œstrogenicity5,6.
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Nicol, T., Snell, R. S., and Bilbey, D. L. J., Brit. Med. J., ii, 800 (1956).
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BILBEY, D., NICOL, T. Effect of Various Natural Steroids on the Phagocytic Activity of the Reticulo-Endothelial System. Nature 182, 674 (1958). https://doi.org/10.1038/182674a0
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DOI: https://doi.org/10.1038/182674a0
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