Abstract
DURING the course of other investigations, oxy-chlororaphin was found to inhibit strongly the growth of Streptomyces sp. 441. Chlororaphin (melting point 225° C. in nitrogen) was separated directly by centrifuging a five-day-old submerged culture of Pseudomonas aeruginosa containing glycerol (Sierra, G., and Veringa, H. A., unpublished work). Yields as great as 0.53 gm./l. were obtained (considerably greater than the yield of 5–16 mgm./l. obtained from a 14-day-old glucose culture at 28° C. by Birkofer1). Crystalline oxy-chlororaphin was obtained by dissolving chlororaphin in acetone (discarding the insoluble fraction). After cooling in contact with the air, the solution yielded crystals of oxy-chlororaphin. Several recrystallizations in acetone were necessary to obtain the pure compound (melting point 242° C.).
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Birkofer, L., Chem. Ber., 80, 212 (1947).
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SIERRA, G., VERINGA, H. Effect of Oxy-chlororaphin on the Growth in vitro of Streptomyces Species and Some Pathogenic Fungi. Nature 182, 265 (1958). https://doi.org/10.1038/182265a0
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DOI: https://doi.org/10.1038/182265a0
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