Abstract
IN previous studies1 on the growth of the HFEM strain of herpes virus in HeLa cells, attempts were made to estimate the proportion of infected cells by inoculating the intact calls on to the chorioallantois of fertile hens' eggs and determining the number which formed pocks. It is known that the chorioallantois is at least ten times more sensitive than HeLa cells to this strain of virus released from HeLa cells. Nevertheless, the proportion of infected (pock-forming) cells was much lower than would be expected from the deduced input of HeLa infective virus, and it was concluded that the cells might not survive long enough to make virus in this environment.
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References
Stoker, M. G. P., and Ross, R. W., J. Gen. Microbiol., 19, 250 (1958).
Wildy, P., Stoker, M. G. P., and Ross, R. W., J. Gen. Microbiol. (in the press).
Farnham, A. E., Virology (in the press).
Stoker, M. G. P., Soc. Gen. Microbiol. Symp., “Virus Growth and Variation” (in the press).
Ross, R. W., and Orlans, E., J. Path. Bact., 76, 393 (1958).
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STOKER, M. Mode of Intercellular Transfer of Herpes Virus. Nature 182, 1525–1526 (1958). https://doi.org/10.1038/1821525a0
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DOI: https://doi.org/10.1038/1821525a0
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