Abstract
DRUG-INDUCED opacities of the lens of the eye have been recorded by Busche1 using nitrophenol compounds in chicken. He was unable to produce this in any other small animals except in one particular strain of mice. While investigating the acute toxic effects of a series of reversed esters of pethidine, we observed that a number of these also produced an opacity. This was completely reversible and has been obtained by using other analgesic drugs in several strains of mice.
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References
Busche, W., Amer. J. Ophth., 30, 1356 (1947).
Haffner, F., Dtsch. med. Wschr., 55, 731 (1929).
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WEINSTOCK, M., STEWART, H. & BUTTERWORTH, K. Lenticular Effect in Mice of Some Morphine-like Drugs. Nature 182, 1519–1520 (1958). https://doi.org/10.1038/1821519a0
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DOI: https://doi.org/10.1038/1821519a0
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