Abstract
RECENTLY, Erspamer1 has reported that the urine of adult rabbits, guinea pigs and horses contains no detectable 5-hydroxyindoleacetic acid, which is found in the urine of men, dogs and rats as an important metabolic product of endogenous serotonin. He has suggested that in adult herbivores the metabolic pathway for serotonin may differ from that in carnivorous and omnivorous mammals. We have therefore investigated whether oxidative deamination is only the first step of a more radical breakdown process, which may even involve the rupture of the indole ring.
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References
Erspamer, V., J. Physiol., 127, 118 (1955).
Weisbach, H., Redfield, R., and Udenfriend, S., J. Biol. Chem., 229, 953 (1957).
Blaschko, H., and Hellmann, K., J. Physiol., 122, 419 (1953).
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NAKAI, K. Serotonin Metabolism in Herbivores. Nature 181, 1734–1735 (1958). https://doi.org/10.1038/1811734a0
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DOI: https://doi.org/10.1038/1811734a0
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