Abstract
IN the course of investigations into the metabolism of phospholipids by nervous tissue, it was observed that lysolecithin had a very marked clearing action on aqueous homogenates of whole rat brain. The hæmolytic action of this compound has been studied fairly extensively (see Collier1), and its effects on isolated liver mitochondria have also recently been investigated (Nygaard, Dianzani and Bahr2), but there appear to be no reports of its action on suspensions of whole tissues.
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References
Collier, H. B., J. Gen. Physiol., 35, 617 (1952).
Nygaard, A. P., Dianzani, M. U., and Bahr, G. F., Exp. Cell. Res., 6, 453 (1954).
Rhodes, D. N., and Lea, C. H., Biochem. J., 65, 526 (1957).
Long, C., and Penny, I. F., Biochem. J., 65, 382 (1957).
Gorter, E., and Hermans, J. J., Rec. trav. Chim. Pay-Bas, 62, 681 (1943).
Collier, H. B., and Chen, H. L., Canad. J. Res. (E), 28, 289 (1950).
Morrison, L. R., and Zamecnik, P. C., Arch. Neurol. Psychiat., Chicago, 63, 367 (1950).
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WEBSTER, G. Clearing Action of Lysolecithin on Brain Homogenates. Nature 180, 660–661 (1957). https://doi.org/10.1038/180660a0
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DOI: https://doi.org/10.1038/180660a0
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