Abstract
GRANULOMA formation is one of the significant reaction patterns of the body in disease. Characterized by tubercles of closely packed epithelioid cells, granulomas are the basic alteration in such chronic diseases as tuberculosis, leprosy, syphilis, sarcoidosis, deep fungus infections and in reactions to foreign material. These epithelioid cells are of reticulo-endothelial origin and may be regularly produced by the introduction of colloidal materials1,2 Other than this, little is known concerning their origin. The present communication describes the production of a specific, hypersensitive, delayed reaction to zirconium which manifested itself as a granuloma.
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References
Warner, N. E., and Friedman, N. B., Ann. Int. Med., 45, 662 (1956).
Ungar, J., Ciba Foundation Symposium on Experimental Tuberculosis, 69 (Little Brown and Co., Boston, 1955).
Rubin, L., Slepyan, A. H., Weber, L. F., and Neuhauser, I., J. Amer. Med. Assoc., 162, 953 (1956).
Shelley, W. B., and Hurley, H. J., Brit. J. Dermat. (in the press).
Helwig, E. B., Mil. Surg., 109, 540 (1955).
Epstein, E., Arch. Derm. and Spyh., 71, 24 (1955).
Sterner, J. H., Eisenbud, N., Arch. Indust. Hyg. and Occ. Med. 4, 123 (1951).
Bohrod, M. G., “Progress in Allergy” (Kallos), 4, 33 (Karger, Basle).
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SHELLEY, W., HURLEY, H. Experimental Evidence for an Allergic Basis for Granuloma Formation in Man. Nature 180, 1060–1061 (1957). https://doi.org/10.1038/1801060a0
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DOI: https://doi.org/10.1038/1801060a0
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