Abstract
IT has been shown that the free-radical content of tissue increases during metabolism1 and the possible importance of free-radical states in carcinogenesis has been discussed by many authors. In particular, it has been suggested that the free-radical state of carcinogens is stabilized as an ion2. The simplest way of producing an ion from a neutral molecule is by the addition or removal of an electron, the former being more likely in tissue owing to the low oxidation-reduction potential3.
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NASH, T. Chemical Carcinogenesis. Nature 179, 868 (1957). https://doi.org/10.1038/179868a0
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DOI: https://doi.org/10.1038/179868a0
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