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Restoration of Sodium-deficient Frog Nerve Fibres by Onium Ions

Nature volume 179, pages 737–738 (1957)Cite this article

Abstract

SINCE guanidinium ions have proved to be able to restore conduction of impulses by sodium-deficient frog A fibres1, it seemed desirable to ascertain whether other ionized compounds possessing a tetracovalent nitrogen atom (onium ions) also can substitute for sodium. An extensive, but not exhaustive, research has revealed that, in addition to guanidinium ions, five onium ions can restore conduction by sodium-deficient frog A fibres: formamidinium, amino-guanidinium, hydrazinium, hydroxylammonium and ammonium ions.

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References

  1. Larramendi, L. M. H., Lorente de Nó, R., and Vidal, F., Nature, 178, 316 (1956).

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  2. Yost, D. M., and Russell, jun., H., “Systematic Inorganic Chemistry” (Prentice-Hall, Inc., New York, 1944).

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  3. Gallego, A., and Lorente de Nó, R., J. Gen. Physiol., 35, 227 (1951).

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Authors and Affiliations

  1. Rockefeller Institute for Medical Research, New York

    R. LORENTE DE Nó, F. VIDAL & L. M. H. LARRAMENDI

Authors
  1. R. LORENTE DE Nó
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  2. F. VIDAL
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  3. L. M. H. LARRAMENDI
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LORENTE DE Nó, R., VIDAL, F. & LARRAMENDI, L. Restoration of Sodium-deficient Frog Nerve Fibres by Onium Ions. Nature 179, 737–738 (1957). https://doi.org/10.1038/179737b0

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